Status:
COMPLETED
Airway Protective Mechanisms in PD (R01)
Lead Sponsor:
University of Florida
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Parkinson Disease
Eligibility:
All Genders
45-85 years
Brief Summary
This study will collect data on various aspects of airway sensation and function, and determine how it relates to the development of swallowing and cough dysfunction in Parkinson's disease. Participan...
Detailed Description
Aspiration pneumonia (APn) occurs at a disproportionately hig rate in patients with Parkinson's disease (PD) versus healthy age-matched older adults. This is of particular public health concern given ...
Eligibility Criteria
Inclusion
- Between the ages of 45 and 85 years
- Diagnosis of PD, Hoehn and Yahr stages I - IV, by a fellowship trained neurologist arriving at the diagnosis of PD by applying strict UK brain bank criteria (PD participants only)
Exclusion
- Neurological disorders other than PD (i.e., stroke, etc.)
- Difficulty complying due to neuropsychological dysfunction (i.e., severe depression)
- Allergy to capsaicin or hot peppers
- History of head or neck cancer
- History of smoking in the past 5 years
- Any neurological disorder including PD (Healthy control group only)
Key Trial Info
Start Date :
December 12 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 29 2023
Estimated Enrollment :
119 Patients enrolled
Trial Details
Trial ID
NCT03321019
Start Date
December 12 2017
End Date
September 29 2023
Last Update
October 10 2024
Active Locations (1)
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1
University of Florida Center for Movement Disorders and Neurorestoration
Gainesville, Florida, United States, 32611