Status:
COMPLETED
Evaluation of the Expression and Functions of the KIR3DL2 Receptor and the Anti-inflammatory Activity of IPH4102 in Blood Samples
Lead Sponsor:
Assistance Publique Hopitaux De Marseille
Conditions:
Axial Spondyloarthritis (axSpA)
Ankylosing Spondylitis (AS)
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
the main objectives are 1. to study the pathophysiological role of KIR3DL2 in axSpA and its relationship with Th17 immunity in HLA-B27 + and HLA-B27- patients and 2. to assess the effect on the pro-i...
Eligibility Criteria
Inclusion
- Informed consent of the patient signed before any procedure planned to the protocol
- SPA axial according to the criteria of the ASAS (international Assessment of SpondyloArthritis Society)
- Known Status HLA B27
- Disease activates with a score of BASDAI = 4/10. The BASDAI (Bath Ankylosing Spondylitis Disease Activity Score) is a composite indication(index), validated, used in the therapeutic essays and in current practice for the evaluation of the activity of the SPA.
- Naive Patients of thorough treatment
- Patients of 18 and more years old
Exclusion
- Minors
- Pregnant or breast-feeding Women
- Adults under guardianship
- People staying in a sanitary or social establishment
- People in emergency situation
- Not profitable People of a national insurance scheme
- Private persons of freedom
- Treatment by corticoids during the last 30 days before the inclusion
- Treatment by anti-TNF or quite different biomedicine
- Treatment by sulfasalazine
- Reached concomitant by another active chronic inflammatory disease
- Infection chronicles by VHB, VHC or HIV
- Patients included in another study of clinical trial
Key Trial Info
Start Date :
December 18 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 17 2019
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT03322618
Start Date
December 18 2017
End Date
September 17 2019
Last Update
September 1 2022
Active Locations (1)
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1
Assistance Publique Hopitaux de Marseille
Marseille, France, 13354