Status:
RECRUITING
Immune Responses in Health Care Personnel
Lead Sponsor:
Finnish Institute for Health and Welfare
Collaborating Sponsors:
Hospital District of Helsinki and Uusimaa
Conditions:
Influenza
Eligibility:
All Genders
18-64 years
Brief Summary
This is an investigator-initiated 10 year long open cohort observational study, aiming to increase the understanding of the humoral and cellular immunological mechanisms of vaccination against influen...
Detailed Description
Influenza vaccination is given according to the normal routine of Hospital District of Helsinki and Uusimaa (HUS) occupational health care. Blood samples will be collected before vaccination, 5 weeks ...
Eligibility Criteria
Inclusion
- Members of health care or laboratory personnel in HUS having decided to take the seasonal influenza vaccination by the routine occupational health care service
- General good health as established by or volunteer's own statement
- Written informed consent
- Presumably able and willing to participate in the study during the starting influenza season
Exclusion
- Any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection.
- Administration (longer than 14 days) of immunosuppressants or other immune- modifying drugs within 6 months before the vaccination; oral corticosteroids in dosages of 20 mg/day or more prednisolone or equivalent are excluded; inhaled or topical steroids are allowed.
- Pregnancy or lactation
- Acute disease at the time of enrolment (defined as the presence of a moderate or severe illness with or without fever)
- Contraindication for influenza vaccination
- Any other criteria which, in the investigator's or dedicated study staff member's opinion, would compromise the ability of a subject to participate in the study, a subject's well-being, or the outcome of the study
Key Trial Info
Start Date :
October 18 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 14 2027
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT03323112
Start Date
October 18 2017
End Date
October 14 2027
Last Update
August 20 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The Hospital District of Helsinki and Uusimaa
Helsinki, Finland