Status:
COMPLETED
Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study
Lead Sponsor:
Wills Eye
Collaborating Sponsors:
Optovue
Conditions:
Glaucoma; Drugs
Normal Tension Glaucoma
Eligibility:
All Genders
18-90 years
Phase:
PHASE4
Brief Summary
This study evaluates the possible acute changes in peripapillary blood flow after instillation of antiglaucoma medications in patients with primary open angle glaucoma (POAG), normal tension glaucoma ...
Detailed Description
Reduction of intraocular pressure (IOP) with topical antihypertensive medications is the mainstay of initial treatment in patients with OHTN, POAG, and NTG. Many patients, however, continue to experie...
Eligibility Criteria
Inclusion
- Diagnosis of ocular hypertension, primary open angle glaucoma, or normal tension glaucoma in the study eye(s)
- Age 18-90
- Best corrected visual acuity of 20/60 or better
Exclusion
- Current use of either brimonidine or timolol
- Other disease, ophthalmic or systemic, that is likely to significantly affect the OCT test in the study eye(s) including:
- More than moderate grade cataract that significantly reducing OCTA scan signal level
- Macular degeneration other than mild drusen or pigmentary changes
- Diabetic retinopathy other than mild background non proliferative retinopathy
- Prior or current macular edema
- Prior laser treatment to the retina
- Prior retinal detachment
- Prior central serous retinopathy
- Prior retinal vein or artery occlusion
- Prior inflammatory retinopathy or choroidopathy
- Keratoconus or other corneal ectasia
- Corneal scarring in central 4 mm
- Prior penetrating keratoplasty
- Ischemic optic neuropathy
- Dementia beyond early/mild memory loss
- History of cerebrovascular accident
- History of severe carotid stenosis
- History of previous ocular surgery other than non-complicated cataract extraction
Key Trial Info
Start Date :
July 10 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 30 2020
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT03323164
Start Date
July 10 2017
End Date
May 30 2020
Last Update
December 31 2020
Active Locations (1)
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1
Glaucoma Research Center - Wills Eye Hospital
Philadelphia, Pennsylvania, United States, 19107