Status:
COMPLETED
Effects of Intraoperative GDFT on the Postoperative Brain Edema
Lead Sponsor:
Beijing Tiantan Hospital
Conditions:
Fluid Therapy
Brain Edema
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Whether a fluid protocol aiming for protecting vital organ perfusion or fluid restriction is favorable to post-craniotomy outcomes such as brain edema remains uncertain. To our knowledge, there has be...
Eligibility Criteria
Inclusion
- Preoperative brain image indicating high-grade glioma (HGG), verified by postoperative histology of the World Health Organization (WHO) as grade III or IV tumors.
- Age 18-65 years, and American Society of Anaesthesiologists (ASA) physical status I to III.
- Signed informed consent.
Exclusion
- Renal insufficiency or the creatinine clearance is \< 30 mL/kg.
- Heart disease, New York Heart Association Functional Classification (NYHA) class II or higher heart failure, or if their cardiac ejection fraction is \< 20%.
- Chronic obstructive pulmonary disease.
- Extensive peripheral arterial occlusive disease.
- Coagulopathy.
- Surgery in the prone position.
- Recurrent carcinoma or tumor in the brain ventricular.
- Body Mass Index \<18.5 kg·m-2 or \>30.0 kg·m-2.
- Awake craniotomy.
Key Trial Info
Start Date :
November 26 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 31 2022
Estimated Enrollment :
480 Patients enrolled
Trial Details
Trial ID
NCT03323580
Start Date
November 26 2018
End Date
October 31 2022
Last Update
March 24 2023
Active Locations (1)
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1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100050