Status:
COMPLETED
Assessment of Pyloric Sphincter Physiology
Lead Sponsor:
Asian Institute of Gastroenterology, India
Conditions:
Physiology of Pyloric Sphincter
Eligibility:
All Genders
18-60 years
Brief Summary
Pylorus is a tubular structure which contains circular muscle, forming pyloric sphincter which separates stomach and duodenum. The motor activity of the pyloric sphincter is less investigated. Antrodu...
Detailed Description
Objective: To evaluate the motor activity of pyloric sphincter using Endo FLIP in the form of pressure, diameter, cross-sectional area (CSA) and distensibility in the healthy volunteers. Methods 20 ...
Eligibility Criteria
Inclusion
- Adult \>18 years and \< 60 years, Both males and females.
- Healthy volunteers willing to give written informed consent.
Exclusion
- Patient younger than 18 years or older than 80 years
- Pregnancy or breast feeding
- Previous history of esophago-gastric surgery or vagotomy
- Previous history of Parkinson disease or diabetes mellitus
- Contra-indication to upper gastro-intestinal endoscopy
- Esophageal varices
- Esophageal diameter smaller than 5 mm
- Contra-indication to general anesthesia
- Hiatal hernia greater than 3 cm on endoscopy
- Esophageal or gastric cancer otherwise than superficial lesion with indication of submucosal dissection
- Typical symptoms (heartburn, regurgitation) of gastro-esophageal reflux disease and/or gastroesophageal reflux disease (GERD)-Q score greater or equal to 8
- Nausea, vomiting or epigastric pain
- Dysphagia with Sydney score greater or equal to 50
- Incapability to give consent
- No written informed consent
- Participation to another study at the same time
Key Trial Info
Start Date :
December 31 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 30 2019
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03324074
Start Date
December 31 2018
End Date
April 30 2019
Last Update
July 2 2019
Active Locations (1)
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1
Rakesh K
Hyderabad, Telangana, India, 500082