Status:
COMPLETED
Exercise and Disease Progression in Amyotrophic Lateral Sclerosis Patients
Lead Sponsor:
University of Lisbon
Conditions:
Amyotrophic Lateral Sclerosis
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
This study evaluated the influence of a tailored aerobic exercise protocol on the functional outcome in ALS patients. In addition, the investigators compare some CPET variables collected during exerci...
Detailed Description
This work aimed to evaluate the effects of a moderate aerobic exercise with controlled intensity determined by Cardiopulmonary Exercise Testing (CPET) and its role on the functional status in ALS pati...
Eligibility Criteria
Inclusion
- Consecutive patients diagnosed with definite, probable, or probable laboratory supported ALS
- Disease duration from first symptoms between 6-24 months to exclude slow and fast progression
- ALSFRS-R ≥ 30
- FVC (%predicted) ≥ 70%
Exclusion
- Other medical conditions, like cardiac insufficiency and lung disorders or others conditions limiting exercise training;
- Heavy smoking habits with laboratorial evidence of significant bronchial constriction;
- Signs of associated dementia or psychiatric disorders.
- Note: None of the patients were on tube feeding, invasive or non-invasive mechanical ventilation at admission of study protocol (T1).
Key Trial Info
Start Date :
July 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2015
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT03326622
Start Date
July 1 2013
End Date
June 30 2015
Last Update
November 1 2017
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