Status:
COMPLETED
The Role of Muscle Protein Breakdown in the Regulation of Muscle Quality in Frail Elderly Individuals
Lead Sponsor:
Truls Raastad
Collaborating Sponsors:
University of Padova
University of Copenhagen
Conditions:
Sarcopenia
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
The purpose of this study is to investigate mechanisms underlying the reduction in muscle quality (the ratio between muscle strength and muscle size) with aging, and to investigate how these factors a...
Detailed Description
Aging is associated with impaired skeletal muscle function. This is evident not only by a reduced capacity to generate force and power at the whole muscle level, but also by a decline in individual mu...
Eligibility Criteria
Inclusion
- Age \> 65
- Frail or pre-frail according to the Fried Frailty Criteria or Short Physical Performance Battery (SPPB) score \<6.
- Mini Mental State Examination score \> 18
Exclusion
- Diseases or injuries contraindicating participation
- Lactose intolerance
- Allergy to milk
- Allergy towards local anesthetics (xylocain)
- Use of anticoagulants that cannot be discontinued prior to the muscle biopsy
Key Trial Info
Start Date :
September 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2018
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT03326648
Start Date
September 1 2016
End Date
March 1 2018
Last Update
April 11 2018
Active Locations (1)
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1
Norwegian School of Sport Sciences
Oslo, Norway, 0863