Status:
COMPLETED
Adenosine and A2A Receptors in Human Brown Adipose Tissue
Lead Sponsor:
Turku University Hospital
Collaborating Sponsors:
University of Bonn
Conditions:
Obesity
Eligibility:
MALE
18-40 years
Phase:
NA
Brief Summary
This study investigates the significance of adenosine and A2A receptors in human brown adipose tissue (BAT) in vivo. Using positron emission tomography (PET), perfusion and the density of A2A receptor...
Detailed Description
Adenosine is a purine nucleoside released locally in BAT when noradrenaline and ATP are released from sympathetic nerves. Recently it was found that adenosine activates murine and human brown adipocyt...
Eligibility Criteria
Inclusion
- Male sex
- BMI 20 - 28 kg/m2
- Age: 18- 40 years
- Normal OGTT
- Healthy, no regular medication
Exclusion
- BMI \< 20 kg/m2 or BMI \> 28 kg/m2
- Low or high blood pressure
- Asthma or other obstructive lung disease
- Sick sinus syndrome, prolonged QT-interval, or any heart disease
- Any chronic disease that could affect the study outcome, including diabetes
- Mental disorder or poor compliance
- Eating disorder or excessive use of alcohol, tobacco smoking or drug use
- Past dose of radiation
- Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
Key Trial Info
Start Date :
November 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2016
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT03327168
Start Date
November 1 2015
End Date
June 30 2016
Last Update
November 6 2017
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