Status:
COMPLETED
Short Term Choline and Cardiovascular Health
Lead Sponsor:
Virginia Polytechnic Institute and State University
Conditions:
Cardiovascular Risk Factor
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to be pred...
Eligibility Criteria
Inclusion
- 18-65 years old, healthy, non-smoking weight stable for previous 6 months (±2.0 kg), BMI\<35 kg/m\^2, verbal and written informed consent, approved for participation by study medical director (Jose Rivero, M.D.)
Exclusion
- Smoking, pregnancy, obese (BMI\>35 kg/m\^2), altered dietary patterns within the last month of recruitment, vegetarians, vegans, unstable heart disease or diabetes, untreated high blood pressure or high cholesterol, allergies to choline supplement, taking any medications that could affect the results (ex., aspirin, antibiotics, pre/probiotics 1 month prior to enrollment), those with trimethylaminuria
Key Trial Info
Start Date :
May 8 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 21 2023
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03327805
Start Date
May 8 2019
End Date
November 21 2023
Last Update
March 21 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Virginia Polytechnic and State University
Blacksburg, Virginia, United States, 24061