Status:
COMPLETED
Timing of Antihypertensive Medications on Key Outcomes in Hemodialysis
Lead Sponsor:
Stanford University
Collaborating Sponsors:
Satellite Healthcare
Conditions:
ESRD
Hemodialysis Complication
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
For patients with kidney failure requiring hemodialysis treatment, sometimes the blood pressure will drop too low during dialysis. In an effort to prevent that from occurring, patients are frequently ...
Detailed Description
High blood pressure (BP) is a major modifiable risk factor for cardiovascular disease, and upwards of 90% of patients with end- stage renal disease (ESRD) have high BP. Appropriate BP management, ther...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- On in-center thrice weekly hemodialysis
- Dialysis start time in the morning
- Taking at least one antihypertensive medication
Exclusion
- Initiation of hemodialysis within previous 90 days
- Inability to provide informed consent
- Currently participating in another clinical trial (intervention study)
- \>2 unexcused missed dialysis sessions in the previous 30 days
- Documented heart failure with reduced ejection fraction (left ventricular ejection fraction \< 40%)
- Cardiovascular event (e.g. myocardial infarction, stroke, heart failure) or procedure (e.g., coronary artery bypass, peripheral arterial bypass grafting, carotid artery procedures, aortic procedures) or hospitalization for unstable angina within the previous 90 days
- End-stage liver disease
- Planned kidney transplant within the next 90 days
- Planned dialysis modality switch (to home hemodialysis, peritoneal dialysis, nocturnal hemodialysis) within the next 90 days
- Pregnancy, currently trying to become pregnant
- Active infection requiring antibiotic, antifungal or antiviral therapies
- Any factors judged by the treatment team to be likely to limit adherence to the interventions
- Active alcohol or substance abuse within the last 12 months
- Plans to move outside of the treatment area within in the next 90 days
- Other medical, psychiatric, or behavioral factors that in the judgement of the study team may interfere with study participation or the ability to follow the intervention protocol
Key Trial Info
Start Date :
July 16 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 14 2019
Estimated Enrollment :
131 Patients enrolled
Trial Details
Trial ID
NCT03327909
Start Date
July 16 2018
End Date
December 14 2019
Last Update
August 23 2022
Active Locations (2)
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1
Satellite Health Care
Menlo Park, California, United States, 94025
2
Satellite Health Care
San Carlos, California, United States, 94070