Status:
UNKNOWN
Combined Use of Low-dose Sugammadex Plus Neostigmine Administered for Reversal of Rocuronium
Lead Sponsor:
Iuliu Hatieganu University of Medicine and Pharmacy
Conditions:
Incidence of Postoperative Residual Curarization
Eligibility:
All Genders
16-65 years
Phase:
EARLY_PHASE1
Brief Summary
Reversal of rocuronium-induced neuromuscular block by the combination of low-doses of neostigmine plus sugammadex decreases the cost of anesthetic medications, while maintaining efficacy of reversal i...
Detailed Description
Background Neuromuscular paralysis is a frequent requirement to facilitate airway management and surgery. Patients receiving neuromuscular blocking agents (NMBAs) are at risk of residual neuromuscular...
Eligibility Criteria
Inclusion
- Patients scheduled for elective abdominal surgery
- 16-65 years of age
- BMI 30-39.9 ( obese class I-II)
- American Society of Anesthesiologists (ASA) physical status II.
- Surgery scheduled for general anesthesia and tracheal intubation and planned extubation at the end of surgery
- Surgical procedures with an anticipated length of at least 60 min.
Exclusion
- Emergency surgery
- Patients unable to consent to study participation
- Patients expected to be maintained on mechanical ventilation postoperatively
- Contraindication to any of the study drugs
- Patients with existing neuromuscular disease
- Acute or chronic renal failure (GFR-EPI \<30 mL/min/1.73 m2)
- Acute/chronic liver disease (Child-Pugh Score \>1)
- Hyperkalemia (\> 5.3 mmol/l)
- Pregnancy
- History of stroke or ongoing paresis
- Glaucoma
- Breast feeding
- Sepsis
Key Trial Info
Start Date :
December 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2018
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT03328312
Start Date
December 1 2017
End Date
June 1 2018
Last Update
November 1 2017
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