Status:
TERMINATED
Mitochondrial Function in Transthyretin Amyloidosis
Lead Sponsor:
University Hospital Center of Martinique
Conditions:
Cardiac Amyloidosis
Eligibility:
All Genders
18+ years
Brief Summary
Hereditary (familial) amyloidosis arising from the misfolding of a mutated or variant transthyretin, is the most frequent form of amyloid cardiomyopathy in the Caribbean basin. Affected organs invaria...
Detailed Description
Systemic amyloidosis are a family of diseases induced by misfolded and/or misassembled proteins. Extracellular deposits of these proteins disrupt vital organ function. Two types of amyloid commonly in...
Eligibility Criteria
Inclusion
- Have a parietal thickness measuring more than 15 mm on the echocardiography or have structural and echogenicity abnormalities characteristic of cardiac amyloidosis,
- Live in Martinique,
- Accept the use of the residues coming from biopsies of the subcutaneous abdominal adipose tissue performed during the medical care.
Exclusion
- Be under 18 years old,
- Have a contraindication to subcutaneous biopsy,
- Be allergic to local anesthetics,
- Pregnant or nursing woman,
- Have a cardiovascular disease suggesting a secondary cardiac disease, such as documented severe hypertension, valvular stenosis, or a known familial cardiomyopathy,
- Be major under guardianship / curatorship or deprived of liberty,
- Not be able to answer to a simple administrative questionnaire or to give freely its non-opposition.
Key Trial Info
Start Date :
July 17 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 29 2019
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT03328338
Start Date
July 17 2018
End Date
December 29 2019
Last Update
August 28 2023
Active Locations (1)
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1
CHU de Martinique
Fort-de-France, Martinique, 97261