Status:
COMPLETED
Intraosseous With Intra-articular Injection of Platelet Rich Plasma in Treatment of Knee Osteoarthritis
Lead Sponsor:
Cangzhou Central Hospital
Conditions:
Osteoarthritis, Knee
Eligibility:
All Genders
40-73 years
Phase:
EARLY_PHASE1
Brief Summary
The aim of this study was to compare the efficacy of treatment in three groups of patients with knee osteoarthritis (OA) given a combination of intraosseous with intra-articular injection of platelet ...
Detailed Description
Methods Eighty-six patients from January 2015 to June 2015 with grade II to grade III knee osteoarthritis according to the Kellgren-Lawrence classification were randomly divided into 3 groups to recei...
Eligibility Criteria
Inclusion
- Unilateral symptomatic knee with pain for at least 1 month or swelling.
- Radiographic findings of knee degeneration (Kellgren-Lawrence score of II - III).
- Age 40-73 years.
- Body mass index (BMI) 18-32.5).
- Knee stability without a severe trauma history.
Exclusion
- Bilateral knee osteoarthritis indicative of treatment for both knees.
- Kellgren-Lawrence score greater than III.
- BMI \>32.
- Age \>73 years.
- Systemic autoimmune rheumatic diseases and blood disorders.
- Active immunosuppressive or anticoagulant therapy.
- Intra-articular injection to the knee within the previous 1 year or previous joint infection.
- use of corticosteroids for 3 weeks before the procedure.
- use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the 3 weeks before treatment.
Key Trial Info
Start Date :
January 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2017
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT03329235
Start Date
January 1 2015
End Date
January 1 2017
Last Update
November 1 2017
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