Status:
COMPLETED
Quality of Life and Health Utility of Patients With CHB Infections
Lead Sponsor:
The University of Hong Kong
Collaborating Sponsors:
Hospital Authority, Hong Kong
Conditions:
Chronic Hepatitis B Infection
Eligibility:
All Genders
18+ years
Brief Summary
The aim of the study is to assess the health-related quality of life (HRQOL) and preference-based health utilities of chronic hepatitis B (CHB) carriers in different stages of illness. It will also es...
Detailed Description
Design, Setting \& Subjects: A cross-sectional study and biomathematical modelling will be carried out. In the cross-sectional study, patients known to CHB carriers will be identified from the registr...
Eligibility Criteria
Inclusion
- Subjects will be included in the study if they:
- Are 18 years and above in age;
- Are known to be HBsAg positive for more than six months;
- Can be classified into one of the following sages of liver diseases:
- (i) Uncomplicated CHB: Patients with chronic CHB infections but normal liver function and without cirrhosis or HCC.
- (ii) CHB with impaired liver function or compensated cirrhosis, not on anti-viral treatment.
- (iii) CHB with impaired liver function or compensated cirrhosis, on anti-viral treatment.
- (iv) Decompensated cirrhosis: Patients with CHB infection and cirrhosis complicated by one or more of the following: variceal bleeding, hepatic encephalopathy or ascites.
- (v) Hepatocellular Carcinoma: Patients with confirmed diagnosis of HCC
- d. Have given written consent to take part in the study.
Exclusion
- Subjects will be excluded from the study if they have one of the following:
- Unable to understand and communicate in Chinese Language;
- Known cognitive impairment;
- Diagnosed end-stage non-hepatitis B related chronic illness such as terminal cancer;
- Patients currently abusing alcohol (\>30 units/week) or illegal drugs;
- Co-infection with HIV, hepatitis C virus (HCV) or hepatitis D virus (HDV);
- Post-liver transplant;
- Refuse to give consent.
Key Trial Info
Start Date :
November 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
589 Patients enrolled
Trial Details
Trial ID
NCT03329820
Start Date
November 1 2006
End Date
December 1 2009
Last Update
November 6 2017
Active Locations (1)
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1
Two Regional Hospitals
Hong Kong, Hong Kong