Status:
COMPLETED
Inflammasomes in Cell Death in FTMH, ERM, and RRD
Lead Sponsor:
Allen C. Ho, MD
Collaborating Sponsors:
Mid Atlantic Retina
Conditions:
Retinal Detachment
Full Thickness Macular Hole
Eligibility:
All Genders
18+ years
Brief Summary
Prospective study evaluating the role of inflammasomes in cell death in retinal detachment, full thickness macular hole, and epiretinal membrane. The investigators are collecting vitreous and subretin...
Detailed Description
Photoreceptor cell death is the main cause of vision loss in many retinal disorders, including retinal detachment (RD). While apoptosis is the most studied form of cell death, the investigators believ...
Eligibility Criteria
Inclusion
- Patient of the Wills Eye Hospital Retina service and Mid-Atlantic Retina offices.
- Volunteer patients age 18 years and older.
- Healthy enough to participate in the study.
- Willing and able to consent to participation in the study.
- Diagnosis of rhegmatogenous retinal detachment treated with external drainage of subretainl fluid, rhegmatogenous retinal detachment treated with pars plana vitrectomy, or full thickness macular hole treated with pars plana vitrectomy
Exclusion
- Presence of tractional retinal detachment
- History of trauma
- Presence of proliferative vitreoretinopathy
- History of prior retinal detachment repair or any prior retina surgery or laser treatment e. Any preexisting retinal disease (including diabetic retinopathy, age related macular degeneration, retinal vein or artery occlusion, other retinal vascular disease, inherited retinal degeneration, uveitis)
Key Trial Info
Start Date :
September 8 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2018
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT03332758
Start Date
September 8 2017
End Date
May 1 2018
Last Update
August 17 2018
Active Locations (1)
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1
MidAtlantic Retina-Wills Eye Hospital
Philadelphia, Pennsylvania, United States, 19107