Status:
UNKNOWN
Age-associated Arterial Dysfunction, Western Diet, and Aerobic Exercise: Role of the Gut Microbiome
Lead Sponsor:
University of Colorado, Boulder
Collaborating Sponsors:
University of California, San Diego
Conditions:
Aging
Eligibility:
All Genders
18-79 years
Phase:
NA
Brief Summary
The risk of developing cardiovascular diseases increases with aging largely due to age-related declines in the function of arteries (arterial dysfunction), which are influenced by common lifestyle fac...
Detailed Description
In order to investigate how age-related changes to the gut microbiome, as modulated by Western diet and exercise, influences arterial function in humans, the investigators will capitalize on the plast...
Eligibility Criteria
Inclusion
- Age 18-29 or 60-79 years
- Participating in \< 30 min aerobic exercise \< 2x/wk for \>3 years OR \> 45 min vigorous aerobic exercise \> 4x/wk for \> 3 yrs
- Currently consuming levels of dietary fat intake with the 40th-60th percentile of Americans based on the NHANES survey (29-37% calories from fat)
- Healthy (no clinical disease)
- Body mass index \< 30 kg/m2
- Ankle-brachial blood pressure index \> 0.9
- Total cholesterol \< 240 mg/dl
- Fasting plasma glucose \< 110 mg/dl
- Weight stable in the past 6 months
Exclusion
- Current or past (within 3 months of screening) use of dietary supplements, anti-inflammatory medications, drugs known to affect the gut microbiome (antibiotics, pre/probiotics, antifungals, antivirals, antiparasitics), or gastrointestinal-targeted drugs (proton pump inhibitors, H2 receptor antagonists, laxatives, antidiarrheal medications)
- Current of past (within 5 years) smoking
- Major change in health status in the last 6 months
- Chronic clinical diseases (e.g., inflammatory bowl diseases, cardiovascular disease, diabetes, neurological disorders, dementia or other brain diseases of aging)
Key Trial Info
Start Date :
March 15 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2021
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT03334201
Start Date
March 15 2018
End Date
December 31 2021
Last Update
October 28 2021
Active Locations (1)
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1
University of Colorado Boulder
Boulder, Colorado, United States, 80309