Status:
COMPLETED
Low-dose Ketamine and Postpartum Depression in Parturients With Prenatal Depression
Lead Sponsor:
Peking University First Hospital
Conditions:
Perinatal Depression
Ketamine
Eligibility:
FEMALE
18-45 years
Phase:
PHASE4
Brief Summary
Postpartum depression is common in mothers early after childbirth and produces harmful effects not only on mothers, but also on infants and young children. Parturients with prenatal depression are at ...
Detailed Description
Postpartum depression refers to maternal depression developed early after childbirth, with reported incidences varied from 15% to 20%. The development of postpartum depression produces harmful effects...
Eligibility Criteria
Inclusion
- Parturients with age from 18 to 45 years and scheduled for elective cesarean delivery;
- Prenatal depression score (EPDS) of 10 or higher;
- Provide written informed consents.
Exclusion
- Refused to participate in the study;
- History of schizophrenia or other disease that prevent normal communication before delivery;
- Presence of contraindications to neuraxial anesthesia, including central nervous system diseases (such as poliomyelitis), spinal diseases (such as spinal canal tumor, lumbar disc prolapse, history of spinal trauma), systemic infection (such as sepsis, bacteremia), local infection in the site of puncture, or coagulopathy;
- Severe complications during pregnancy (such as severe preeclampsia, placenta accreta, HELLP syndrome);
- Severe comorbidity before pregnancy (such as severe cardiac dysfunction);
- Scheduled to undergo cesarean delivery under general anesthesia;
- Other reasons that are considered unsuitable for study participation.
Key Trial Info
Start Date :
November 23 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 25 2018
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT03336541
Start Date
November 23 2017
End Date
June 25 2018
Last Update
December 13 2021
Active Locations (1)
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1
Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital
Beijing, Beijing Municipality, China, 100034