Status:
UNKNOWN
Paternally Inherited Phenotypes in Cholestasis
Lead Sponsor:
Guy's and St Thomas' NHS Foundation Trust
Collaborating Sponsors:
King's College Hospital NHS Trust
Conditions:
Cholestasis
Primary Sclerosing Cholangitis
Eligibility:
All Genders
16+ years
Brief Summary
For some years investigators have known that the health of fathers at the time their baby is conceived has an influence on the health of their child in the future. Many studies looking at this effect ...
Eligibility Criteria
Inclusion
- Sperm Epigenome Arm:
- Cholestatic men
- Men who have a diagnosis of a cholestatic liver condition including but not restricted to Primary Sclerosing Cholangitis and Primary Biliary Cholangitis.
- Me who are able and willing to give informed consent.
Exclusion
- Men who have a history of diabetes or obesity.
- Men who have gallstones, cancer or other acute cholestatic pathology.
- Men who have a history of alcohol excess or drug abuse.
- Men who smoke.
- Men who have blood-borne viruses e.g. HIV or hepatitis.
- Men unable or unwilling to give informed consent
- Healthy men
- Inclusion Criteria:
- Men who have no history of cholestasis, liver disease, diabetes or obesity.
- Me who are able and willing to give informed consent.
Key Trial Info
Start Date :
February 8 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 30 2020
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03337074
Start Date
February 8 2017
End Date
April 30 2020
Last Update
August 2 2019
Active Locations (2)
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1
Assisted Conception Unit, Guy's Hospital
London, United Kingdom, SE1 9RT
2
King's College Hospital
London, United Kingdom, SE5 9RS