Status:
COMPLETED
CO2 (Carbon Dioxide) - Cerebral Oxygenation
Lead Sponsor:
University of Zurich
Conditions:
Hypoxia, Brain
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
Several projects in high altitude research in environments with a low oxygen partial pressure (hypobaric hypoxia) leading to hypoxemia showed, that cerebral perfusion and cerebral performance could be...
Detailed Description
On the day of surgery patients will be randomized. After induction of anesthesia and endotracheal intubation patients will be managed by the study team to perform the intervention and the measurements...
Eligibility Criteria
Inclusion
- Patients who are designated for bariatric surgery at the University Hospital Zurich (USZ)
- Informed Consent as documented by signature
- BMI \>35 kg/m2
Exclusion
- Severe end-organ damage: chronic obstuctive pulmonary disease (COPD) GOLD (cassification) III and IV, known hepatic insufficiency or elevated liver enzymes, renal creatinine clearance \<30ml/min
- Severe cardiovascular disease (NYHA classification III and IV)
- Known pulmonary Hypertension
- Cerebrovascular disease
- Pregnancy and lactation
- Cardiac dysrhythmias
- acidosis, chronic pulmonary disease
- Known or suspected non-compliance, drug or alcohol abuse
Key Trial Info
Start Date :
January 25 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 12 2019
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03338907
Start Date
January 25 2018
End Date
February 12 2019
Last Update
February 20 2019
Active Locations (1)
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1
University Hospital Zurich
Zurich, Switzerland