Status:
COMPLETED
Neurovascular Changes Induced by Chemotherapy
Lead Sponsor:
University of Sao Paulo General Hospital
Conditions:
Breast Cancer
Chemotherapeutic Toxicity
Eligibility:
FEMALE
35-65 years
Phase:
NA
Brief Summary
The purpose of the present study was to test the hypothesis that doxorubicin and cyclophosphamide adjuvant chemotherapy (CHT) acutely induces neurovascular and hemodynamic changes in patients with bre...
Detailed Description
The purpose of the present study was to test the hypothesis that doxorubicin and cyclophosphamide adjuvant chemotherapy (CHT) acutely induces neurovascular and hemodynamic changes in patients with bre...
Eligibility Criteria
Inclusion
- Breast cancer patients and prescription of adjuvant chemotherapy with antracycline and cyclophosphamide
Exclusion
- Metastic disease
- Hypercholesterolemia
- Diabetes
- Hypertension
- Severe lymphedema
- Renal insufficient
- Heart failure
- Chronic liver disease
- Obesity, and treatment with some medications that inhibit cardiotoxicity, as beta-blocker angiotensin converting enzyme, statin, losartan and antioxidants.
Key Trial Info
Start Date :
February 22 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2017
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT03339804
Start Date
February 22 2016
End Date
October 1 2017
Last Update
November 13 2017
Active Locations (1)
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1
Heart Institute
São Paulo, Cerqueira Cesar, Brazil