Status:
UNKNOWN
Impact of Perioperative Treatment With Intravenous Glutamine on Myocardial Protection in Cardiac Surgery Patients With Aortic Stenosis
Lead Sponsor:
Yonsei University
Conditions:
Aortic Valve Stenois
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
The purpose of this study is to confirm if myocardial protection effect can be obtained by intravenous administration of glutamine in patients undergoing aortic valve replacement with severe aortic st...
Eligibility Criteria
Inclusion
- Adult patients with between 20 and 80 years scheduled for aortic valve replacement alone or combined surgery including aortic valve replacement due to severe aortic valve stenosis
Exclusion
- Patients with renal insufficiency (eGFR 60 ml / min / 1.73 m 2 or less)
- patients who are considering surgery for coronary artery disease or who have a stenosis\> 70%
- hemodynamically unstable patients undergoing emergency surgery or patients with intra-aortic balloon pump insertion
- patients unable to make their own decisions, illiterate, foreigners
- epilepsy
- severe metabolic acidosis
- pulmonary edema
- history of myocardial infarction
- elevation of total bilirubin or AST / ALT
- Patients higher than normal, weighing more than 80 kg
- with evidence of infection
- pregnant and lactating women
Key Trial Info
Start Date :
March 20 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 28 2019
Estimated Enrollment :
108 Patients enrolled
Trial Details
Trial ID
NCT03341169
Start Date
March 20 2018
End Date
September 28 2019
Last Update
January 10 2019
Active Locations (1)
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1
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine
Seoul, South Korea, 03722