Status:
COMPLETED
Brain Mechanisms of Overeating in Children
Lead Sponsor:
Penn State University
Conditions:
Pediatric Obesity
Inhibition
Eligibility:
All Genders
7-8 years
Brief Summary
The proposed research will follow healthy weight children who vary by family risk for obesity to identify the neurobiological and appetitive traits that are implicated in overeating and weight gain du...
Detailed Description
In aim one, the investigators will use functional magnetic resonance imaging to characterize the brain regions which are activated in response to food portion size and compare these regions between hi...
Eligibility Criteria
Inclusion
- Child is in good health based on parental self-report
- Child has no learning disabilities (e.g., ADHD)
- Child has no diagnosed psychological or medical conditions/devices, or metal in/on the body that may impact comfort or safety in the fMRI (e.g., anxiety, insulin pump)
- Child is not on any medications known to influence body weight, taste, food intake, behavior, or blood flow
- Child is not claustrophobic
- Child is between the ages of 7-8 years-old at enrollment
- Child's immediate family members have not been diagnosed with a psychological disorder, including depression, anxiety, schizophrenia, etc.
- Child's biological mother and biological father have a body mass index either between 18.5 - 25 kg/m2 (low-risk group) or biological mother has a body mass index greater than or equal to 30 kg/m2 and biological father has a body mass index greater than or equal to 25 kg/m2 (high-risk group)
- Child's parent participating in study must be available to attend visits with child
Exclusion
- Child is not in good health based on parent self-report
- Child has any learning disabilities (e.g., ADHD)
- Child has any psychological or medical conditions/devices that may impact comfort in the fMRI (e.g., anxiety, insulin pump)
- Child is taking any medications known to influence body weight, taste, food intake, behavior, or blood flow
- Child is claustrophobic
- Child is less than 7 or greater than 8 years-old at enrollment
- Child has any immediate family members diagnosed with a psychological disorder, including depression, anxiety, schizophrenia, etc.
- Child's biological mother or biological father's body mass index do not fit into the parameters for either group (both biological parents \< 18.5 for low-risk group or biological mother is \< 30 and biological father is \< 25 for high-risk group)
- Child's parent participating in study is not available to attend visits with child
- Child is blue/green colorblind
- Child is not fluent in the English language
Key Trial Info
Start Date :
January 31 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 20 2023
Estimated Enrollment :
254 Patients enrolled
Trial Details
Trial ID
NCT03341247
Start Date
January 31 2018
End Date
June 20 2023
Last Update
January 3 2024
Active Locations (1)
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1
The Pennsylvania State University
University Park, Pennsylvania, United States, 16802