Status:
UNKNOWN
Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis
Lead Sponsor:
Peking Union Medical College Hospital
Collaborating Sponsors:
First Hospitals affiliated to the China PLA General Hospital
Nanjing General Hospital
Conditions:
Pancreatitis, Acute
Hypertriglyceridemia
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
To investigate an economical and effective way to reduce the level of serum triglyceride in patients with hypertriglyceridemia-induced acute pancreatitis.
Eligibility Criteria
Inclusion
- Adult aged 18 to 80 years old;
- abdominal pain consistent with AP;
- serum amylase and / or lipase activity is at least 3 times higher than the normal upper limit;
- abdominal imaging consistent with AP imaging changes.
- severe hyperlipidemia "fasting serum TG\> 1,000 mg/dL (11.2mmol/L)";
- except for other AP causes, such as cholelithiasis, alcohol, drugs and so on.
Exclusion
- other etiologies other than hyperlipidemia leading to AP;
- fasting serum TG less than 1,000 mg / dL (11.2mmol / L);
- acute lipid-induced pancreatitis at the same time combined with other etiologies of acute pancreatitis.
- the existence of plasma replacement contraindications: serious allergies to plasma, human serum albumin, heparin and others; the existence of mental disorders; unstable heart or cerebral infarction; intracranial hemorrhage or severe cerebral edema associated with hernia.
- without informed consent, the patient refused to plasma replacement, and other circumstances may bring significant bias.
Key Trial Info
Start Date :
November 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2020
Estimated Enrollment :
220 Patients enrolled
Trial Details
Trial ID
NCT03342807
Start Date
November 1 2017
End Date
November 1 2020
Last Update
November 17 2017
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