Status:
UNKNOWN
Early Versus Late CRRT in ACLF Patients With Septic Shock and AKI
Lead Sponsor:
Institute of Liver and Biliary Sciences, India
Conditions:
Septic Shock and Acute Kidney Injury
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Consecutive patients with ACLF (Acute on Chronic Liver Failure) and septic shock with AKI (Acute Kidney Injury) who give written informed consent will be included in this prospective trial at ILBS. At...
Eligibility Criteria
Inclusion
- \- Patients with ACLF defined based on APASL criteria with septic shock associated AKI
Exclusion
- Patients with age less than 18 years
- Severe known cardiopulmonary disease (structural or valvular heart disease, coronary artery disease, COPD)
- Pregnancy
- Chronic kidney disease on hemodialysis
- Patients with Hepatorenal Syndrome, post renal obstructive AKI, AKI due to glomerulonephritis, interstitial nephritis or vasculitis
- Patients already meeting emergency criteria for immediate hemodialysis at the time of randomization as specified in the late group (serum potassium\>6 meq/lt, metabolic acidosis ph\<7.12, acute pulmonary edema, severe volume overload with hypoxemia non-responsive to diuretic treatment)
- Patients transferred from other hospitals who have already been on hemodialysis before their arrival in the intensive care unit
- Extremely moribund patients with an expected life expectancy of less than 24 hours
- Failure to give informed consent from family members.
- Hemodynamic instability requiring very high dose of vasopressors
Key Trial Info
Start Date :
September 25 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 25 2018
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT03343340
Start Date
September 25 2017
End Date
September 25 2018
Last Update
November 17 2017
Active Locations (1)
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1
Institute of Liver and Biliary Sciences
New Delhi, National Capital Territory of Delhi, India, 110070