Status:
COMPLETED
Linked Color Imaging Versus High-definition White Light Endoscopy for the Detection of Polyps in Patients With Lynch Syndrome (LCI-LYNCH)
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Collaborating Sponsors:
FUJIFILM Europe GmbH
Conditions:
Lynch Syndrome
Colonoscopy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim of the present study is to compare polyp detection rates of LCI with high-definition white light endoscopy (HD-WLE) in patients with Lynch syndrome in a parallel, international, multicenter, r...
Detailed Description
Rationale: Linked Color Imaging is a push-button endoscopic imaging technique developed to enhance the visibility of the vasculature and architecture of the mucosal surface by narrowing the spectrum o...
Eligibility Criteria
Inclusion
- Diagnosis of Lynch-syndrome, with a germline mutation in one of the MMR genes (MLH1, MSH2, MSH6, PMS2)
- Age \>18 years
- Surveillance colonoscopy for Lynch syndrome.
Exclusion
- Recent surveillance colonoscopy within 1 year from current exam (e.g. after piecemeal EMR) or patients referred for endoscopic evaluation of known colorectal neoplasia.
- Colonoscopy planned for the evaluation of symptoms like rectal blood loss, recent change in bowel habits, weight loss or anemia.
- Patients with a concurrent diagnosis of (serrated) polyposis syndrome or inflammatory bowel disease.
- Patients who are unwilling or unable to give informed consent.
Key Trial Info
Start Date :
January 21 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 9 2020
Estimated Enrollment :
357 Patients enrolled
Trial Details
Trial ID
NCT03344289
Start Date
January 21 2018
End Date
June 9 2020
Last Update
July 14 2020
Active Locations (1)
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1
Academic Medical Centre
Amsterdam, North Holland, Netherlands, 1105AZ