Status:
COMPLETED
Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
National Institute of Nursing Research (NINR)
Conditions:
Osteoarthritis, Knee
Pain
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
Osteoarthritis (OA) in the knee is characterized by chronic inflammatory pain that is not necessarily related to the amount of joint damage. Clinical practice guidelines recommend physical activity (P...
Detailed Description
Osteoarthritis (OA) in the knee is characterized by chronic inflammatory pain that is not necessarily associated with the amount of joint damage.1 Clinical practice guidelines recommend physical activ...
Eligibility Criteria
Inclusion
- Adults with Osteoarthritis:
- Age 50-80
- radiographic evidence of knee osteoarthritis (OA participants)
- self-report current non-smoker
- willing and able to walk for 30 minutes a day three days a week for six weeks at a location that is within 30 minutes from University of Maryland Baltimore
- speaks English
- Healthy Controls:
- Age 50-80
- self-reports no osteoarthritis
- self-report current non-smoker
- willing and able to walk for 30 minutes a day three days a week for six weeks at a location that is within 30 minutes from University of Maryland Baltimore
- speaks English
Exclusion
- unable to pass the evaluation to sign consent
- diagnosis of rheumatoid arthritis
- diagnosis of gout
- diagnosis of heart failure
- diagnosis of chronic obstructive pulmonary disease
- diagnosis of diabetes
- diagnosis of Parkinson's disease
- diagnosis of Alzheimer's disease
- diagnosis of autoimmune disease
- currently taking long-term steroid medications such as methotrexate
- weight less than 110 lbs.
- direct employee of the PI
Key Trial Info
Start Date :
May 7 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 24 2022
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT03344913
Start Date
May 7 2018
End Date
August 24 2022
Last Update
September 7 2022
Active Locations (1)
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1
University of Maryland, Baltimore
Baltimore, Maryland, United States, 21201