Status:
UNKNOWN
The Role of DNA Damage of Granulosa Cell on Oocyte Quality and in Vitro Fertilization Outcome
Lead Sponsor:
Suleyman Demirel University
Conditions:
in Vitro Fertilization
Eligibility:
FEMALE
19-44 years
Brief Summary
Deoxyribonucleic acid (DNA) damage of granulosa cells obtained during oocyte retrieval will be evaluated by comet assay in unexplained infertile patients undergoing in vitro fertilization (IVF) treatm...
Detailed Description
Granulosa cells surrounding the oocytes will be mechanically obtained during the oocyte pick-up procedure in women undergoing in vitro fertilization (IVF) treatment due to unexplained infertility. Deo...
Eligibility Criteria
Inclusion
- Unexplained infertile patients undergoing in vitro fertilization (IVF) treatment
Exclusion
- Chronic systemic disease (rheumatoid arthritis, hypertension, diabetes..)
- Endocrinopathy (Thyroid, prolactin... abnormalities)
- Chemotherapy or radiotherapy history
- Cigarette, alcohol, chronic medication use
- Diminished ovarian reserve
- Endometriosis
- Having any medication use
- History of any surgical procedure on ovaries and uterus
- Smoking or alcohol consumption
- Severe oligoasthenospermia
- Tubal infertility associated with hydrosalpinx, severe pelvic adhesions, endometriosis or pelvic inflammatory disease
Key Trial Info
Start Date :
May 9 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 30 2018
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03345030
Start Date
May 9 2017
End Date
March 30 2018
Last Update
November 24 2017
Active Locations (2)
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1
Esra Nur Tola
Isparta, Cunur, Turkey (Türkiye), 32200
2
Suleyman Demirel University, Faculty of Medicine
Isparta, Cunur, Turkey (Türkiye), 32200