Status:
ACTIVE_NOT_RECRUITING
A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433
Lead Sponsor:
AbbVie
Conditions:
Crohn's Disease
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
A multicenter study to evaluate the efficacy and safety of maintenance and long-term treatment administration of upadacitinib, an orally administered Janus kinase 1 inhibitor, in adult participants wi...
Eligibility Criteria
Inclusion
- For Substudy 1:
- Participant who achieve clinical response in Study M14-431 or Study M14-433.
- Participant completes study procedures in the parent study. The final endoscopy for Studies M14-431 or M14-433 may be missing, if the endoscopy cannot be performed during the COVID-19 pandemic.
- For Substudy 2:
- Participant completes Substudy 1. The Week 52 endoscopy may be missing, if the endoscopy cannot be performed during the COVID-19 pandemic.
- Participant who achieved clinical response at the time described in the protocol and completes study procedures in the parent study/ substudy.
Exclusion
- For Substudies 1 and 2:
- Participant is considered by the investigator, for any reason, to be an unsuitable candidate for the study.
- Participant who has a known hypersensitivity to upadacitinib or its excipients, or had an adverse event during Studies M14-431 and M14-433 or Substudy 1 or 2 of Study M14-430 that in the investigator's judgment makes the participant unsuitable for this study.
- Participant at the final visit of M14-431 or M14-433 with any active or chronic recurring infections based on the investigator's assessment that makes the participant an unsuitable candidate for the study. Participants with serious infections undergoing treatment may be enrolled BUT NOT dosed until the infection treatment has been completed and the infection is resolved, based on the investigator's assessment.
- Participants with high grade colonic dysplasia or malignancy diagnosed at the endoscopy performed at the final visit of Studies M14-431, M14-433 or Substudy 1 of Study M14-430 (Week 52).
Key Trial Info
Start Date :
March 21 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
747 Patients enrolled
Trial Details
Trial ID
NCT03345823
Start Date
March 21 2018
End Date
September 1 2027
Last Update
August 5 2025
Active Locations (466)
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1
East View Medical Research, LLC /ID# 171132
Mobile, Alabama, United States, 36606
2
CB Flock Research Corporation /ID# 166239
Mobile, Alabama, United States, 36608
3
Delsol Research Management, Ll /Id# 170164
Chandler, Arizona, United States, 85224
4
Duplicate_HonorHealth Research Institute - Shea /ID# 164725
Scottsdale, Arizona, United States, 85258