Status:
COMPLETED
Safety of Sugammadex for the Reversal of Neuromuscular Blockade in American Society of Anesthesiologists (ASA) Class 3 or 4 Participants (MK-8616-145)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Reversal of Neuromuscular Blockade
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this trial is to evaluate the safety of sugammadex for the reversal of neuromuscular blockade (NMB) induced by neuromuscular blockade agents (NMBA) rocuronium or vecuronium in adult Ame...
Eligibility Criteria
Inclusion
- Has a body mass index (BMI) \< 40 kg/m2.
- Is categorized as ASA Physical Status Class 3 or 4, as determined by the Investigator.
- Has a planned surgical procedure that requires NMB with either rocuronium or vecuronium.
- Has a planned surgical procedure (e.g., gastrointestinal, urologic, or laparoscopic) that in the opinion of the investigator does not preclude maintenance of moderate or deep depth of NMB throughout the case.
- If female who is not of reproductive potential, is one of the following: (1) postmenopausal; (2) has had a hysterectomy and/or bilateral oophorectomy, bilateral salpingectomy, or bilateral tubal ligation/occlusion at least 6 weeks prior to screening; (3) has a congenital or acquired condition that prevents childbearing; or (4) is undergoing surgical sterilization (e.g., hysterectomy or tubal ligation) as the planned surgical procedure associated with participation in this study.
- If female who is sexually active and of child-bearing potential, agrees to use a medically accepted method of contraception through seven days after receiving protocol-specified medication. Abstinence (relative to heterosexual activity) can be used as the sole method of contraception if it is consistently employed as the subject's preferred and usual lifestyle and if considered acceptable by local regulatory agencies and Ethics Review Committees/Institutional Review Boards.
- Is able to provide (or the participant's legally authorized representative, in accordance with local requirements), written informed consent for the trial. The participant or legally authorized representative may also provide consent for Future Biomedical Research.
Exclusion
- Has a pacemaker or automatic implantable cardioverter-defibrillator that precludes the assessment of bradycardia or arrhythmias.
- Has a medical condition or surgical procedure that precludes reversal of neuromuscular block at the end of surgery.
- Has a neuromuscular disorder(s) that may affect neuromuscular block and/or trial assessments.
- Is dialysis-dependent or has severe renal insufficiency, defined as estimated creatinine clearance of \<30 mL/min.
- Has or is suspected of having a personal history or family history (parents, grandparents, or siblings) of malignant hyperthermia.
- Has or is suspected of having an allergy (e.g., hypersensitivity and/or anaphylactic reaction) to study treatments or its/their excipients, to opioids/opiates, muscle relaxants or their excipients, or other medication(s) used during general anesthesia.
- Has received or is planned to receive toremifene within 24 hours before or within 24 hours after study medication administration.
- Has any condition that would contraindicate the administration of study medication.
- Is pregnant, is attempting to become pregnant, or is lactating.
- Is currently participating in or has participated in an interventional clinical trial (including any other current or ongoing trial with a sugammadex treatment arm) with an investigational compound or device within 30 days of signing the informed consent form of this current trial.
Key Trial Info
Start Date :
December 20 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 4 2019
Estimated Enrollment :
344 Patients enrolled
Trial Details
Trial ID
NCT03346057
Start Date
December 20 2017
End Date
September 4 2019
Last Update
October 8 2020
Active Locations (30)
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1
University of Alabama - Birmingham ( Site 1046)
Birmingham, Alabama, United States, 35233
2
University Banner Medical Center ( Site 1019)
Tucson, Arizona, United States, 85719
3
Loma Linda University Medical Center ( Site 1029)
Loma Linda, California, United States, 92354
4
University of California Davis Medical Center ( Site 1001)
Sacramento, California, United States, 95817