Status:
COMPLETED
Impact of [11C]-Methionine PET/MRI in the Detection of Pituitary Adenomas Secreting ACTH and Causing Cushing's Disease
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Cushing's Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Cushing's disease is characterized by the existence of a benign pituitary tumor developed from corticotropic cells responsible for excessive ACTH secretion. This results in hypercorticism causing high...
Eligibility Criteria
Inclusion
- Aged 18 years old or over
- Patient with a diagnosed Cushing's disease according to the French "protocole national de diagnostic et de soins (PNDS)"
- Patient who underwent a MRI pituitary for diagnostic purposes
- Patient who have undergone catheterization of the lower petrosal sinuses (if MRI does not detect pituitary adenoma) and have a result in favor of a central secretion of ACTH
- Patient having an indication of surgical excision of the adenoma
- Patient with a micro-adenoma (less than 1 cm in diameter) if the tumor is visualized on MRI
- Patient for which informed and written consent to participate has been obtained.
Exclusion
- \- Patient participating in another study
- Patient with a pituitary macro-adenoma with visual impairment
- Patient with ACTH-dependent Cushing's syndrome secondary to ectopic ACTH secretion
- Patient with recurrence and / or history of pituitary adenoma excision
- Patient with a contraindication to pituitary surgery or general anesthesia
- Pregnant woman, breastfeeding or old enough to have children but without effective recognized contraception
- Contra-indication to the realization of an MRI: permanently fixed metal parts (pacemaker, cerebral clip, cephalic end piercing, cochlear implant, pin or screw for recent bone fracture, dental equipment, metal splinters), claustrophobia
Key Trial Info
Start Date :
December 11 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2020
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT03346954
Start Date
December 11 2017
End Date
August 31 2020
Last Update
September 25 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Service de Médecine Nucléaire - Hospices Civils de Lyon
Bron, France, 69677