Status:
UNKNOWN
Microfluidic Organotypic Model for Monocyte Transendothelial Migration to the Joint in Obese Osteoarthritic Patients
Lead Sponsor:
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Conditions:
Osteoarthritis
Eligibility:
All Genders
60-80 years
Brief Summary
Osteoarthritis (OA) is the fastest growing cause of disability worldwide due to population ageing and increasing obesity incidence. Obese individuals have a higher risk of OA insurgence and severe pro...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Obese OA patients
- Subscription of informed consent
- BMI ≥ 30
- age between 60-80 years included
- Kelgrenn-Lawrence equal or superior to grade III
- presence of synovitis
- patients undergoing knee replacement
- suspension of NSAIDs from one week before the surgical procedure according to the standard clinical practice
- Non-obese OA patients
- Subscription of informed consent
- BMI ≤ 28
- age between 60-80 years included
- Kelgrenn-Lawrence equal or superior to grade III
- presence of synovitis
- patients undergoing knee replacement
- suspension of NSAIDs from one week before the surgical procedure according to the standard clinical practice
- Exclusion criteria
- Obese OA patients - HCV, HIV, HBV, TPHA infection
- Non-obese OA patients
- \- HCV, HIV, HBV, TPHA infection
Exclusion
Key Trial Info
Start Date :
December 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2019
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT03347500
Start Date
December 1 2017
End Date
July 1 2019
Last Update
November 20 2017
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