Status:
ENROLLING_BY_INVITATION
Autologous Osteo-periosteal Cylinder Graft Transplantation for Hepple V Osteochondral Lesions of the Talus
Lead Sponsor:
Peking University Third Hospital
Conditions:
Osteochondral; Defect
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The trial evaluates the clinical efficacy and safety of autologous osteo-periosteal cylinder graft transplantation for Hepple V osteochondral lesions of the talus. Half of participants will receive au...
Detailed Description
Autologous osteo-periosteal cylinder graft surface is a periosteal structure, with the ability of repairment to cartilage, periosteum is closely connected to the cortical bone, then the deep loose can...
Eligibility Criteria
Inclusion
- 18-50 years old, male or female
- Chronic pain in the ankle, confirmed by ankle joint MRI as Hepple V osteo-chondral lesions of the talus
- Using rest/external use/oral non-steroidal anti-inflammatory drugs and other conservative treatment for more than 3 months ineffective
- Patients voluntarily participated in clinical trials, signed informed consent, with clinical follow-up
Exclusion
- In the last 6 months patients participated in other drug or medical device clinical trials
- Line of force in ankle is not correct (varus or valgus\> 5 degrees)
- Grade III ankle collateral ligament injury
- Chronic specific synovitis (rheumatoid, pigmented villonodular synovitis, etc.)
- Joint fibrosis, ankylosis, activity was significantly limited
- Moderate and severe osteoarthritis
- There are MRI contraindications
- Hemophilia patients
- The general condition of patients can not tolerate surgery
- Pregnant or planned pregnant women and lactating women
- Abnormal mental capacity without autonomy
- Other conditions in which the doctor can not decide to participate in the trial
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT03347877
Start Date
January 1 2018
End Date
December 31 2026
Last Update
August 27 2025
Active Locations (1)
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1
Institute of Sports Medicine
Beijing, Beijing Municipality, China, 100000