Status:
COMPLETED
The Effects of Ethanol on Intestinal Permeability and Gut Hormones
Lead Sponsor:
University of Copenhagen
Conditions:
Insulin Resistance
Ethanol
Eligibility:
MALE
20-50 years
Phase:
NA
Brief Summary
The aime of this study is to envsitigate if ethanol has an incretin effect. This is done by administration of ethanol orally vs. an isoethanolaemic i.v. infusion of ethanol.
Eligibility Criteria
Inclusion
- Caucasian male between 20 and 50 years of age
- Body mass index (BMI) between 19 and 25 kg/m2
- Weekly alcohol intake of less than 14 units of alcohol (of 12 g)
- Normal fasting plasma glucose concentration (i.e. \<6 mmol/l) and normal glycated haemoglobin A1c (HbA1c) (i.e. ≤42 mmol/mol)
- Normal haemoglobin
- Informed consent
Exclusion
- First-degree relatives with diabetes and/or liver disease
- Liver disease or other alcohol-related diseases, diabetes mellitus
- Liver disease (serum ALAT and/or serum ASAT \>2 × normal values)
- Nephropathy (serum creatinine above normal range and/or albuminuria)
Key Trial Info
Start Date :
August 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2017
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT03348371
Start Date
August 1 2016
End Date
October 1 2017
Last Update
November 20 2017
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