Status:
COMPLETED
[11C]NOP-1A and Cocaine Use Disorders
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Cocaine Use Disorder
Eligibility:
All Genders
18-50 years
Phase:
EARLY_PHASE1
Brief Summary
The goal of this study is to compared \[C-11\]NOP-1A binding in recently abstinent cocaine use disorders and controls.
Detailed Description
This will allow for understanding brain stress and anti-stress mechanisms that underlie abuse of cocaine in humans.
Eligibility Criteria
Inclusion
- \[A\]Cocaine use disorders
- Inclusion criteria:
- Males or Females 18-50
- Fulfill DSM-5 Diagnosis for Cocaine use disorder
- Medically Healthy
- Major exclusion criteria:
- Pregnancy or lactation
- Comorbid medical, psychiatric, drug use disorders (other than cocaine, tobacco use, and recreational marijuana/alcohol use)
- Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan
- Currently employed as radiation worker; or participation in radioactive drug research protocols within the previous year
- Currently on any psychotropic medications that can influence nociceptin transmission in the brain (e.g., morphine, suboxone, SSRIs, etc.)
- \[B\] Healthy controls
- Inclusion criteria:
- Males or Females 18-50
- Absence of present or past psychiatric conditions (including alcohol or drug use disorders)
- A negative urine drug screen
- Medically Healthy
- Major exclusion criteria
- Pregnancy or lactation
- Medical, psychiatric or drug \& alcohol use disorders
- Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan
- Currently employed as radiation worker; or participation in radioactive drug research protocols within the previous year
- Currently on any psychotropic medications that can influence nociceptin transmission in the brain
- Family history of a psychotic disorder, manic episode, drug use disorders in first-degree relatives.
Exclusion
Key Trial Info
Start Date :
October 30 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 20 2019
Estimated Enrollment :
49 Patients enrolled
Trial Details
Trial ID
NCT03348384
Start Date
October 30 2014
End Date
February 20 2019
Last Update
August 5 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213