Status:
COMPLETED
Repetitive Transcranial Magnetic Stimulation as a Treatment for Pain in Parkinson's Disease
Lead Sponsor:
Walton Centre NHS Foundation Trust
Conditions:
Parkinson Disease
Neuropathic Pain
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Transcranial magnetic stimulation (TMS) is a procedure that has been shown to improve pain in chronic sufferers. It is a well-tolerated procedure that can be performed on an outpatient basis. It uses ...
Eligibility Criteria
Inclusion
- Patients who have a diagnosis of Parkinson's Disease.
- Medical treatment for the movement disorder to be optimized prior to the study.
- Despite optimum medical therapy neuropathic pain is a major complaint for the patient:
- A minimum total score on the King's Pain Scale of 12 or
- A minimum subset domain score on Fluctuation-related Pain of 6 or
- A minimum subset domain score on Nocturnal pain of 5 or
- A minimum subset domain score on Radicular Pain of 3 or
- No other cause for the pain is identified.
- Age 18-80
- Weekly average pain levels of 3/10 or more at the time of entry
- The patient is capable of and willing to give informed consent for their participation.
- The patient is capable of and willing to fill in a daily Pain diary during the study.
Exclusion
- Patients will be excluded from the trial if they:
- Are suffering from pain not attributable from Parkinson's Disease
- Are suffering from any neurological or psychiatric disease that could interfere with provision of reliable data (dementia, major depression, drug abuse, alcoholism)
- Are suffering from a rapidly progressing malignant disease or other systemic disease that is likely to significantly interfere with their participation in the study
- Are candidates or have been listed for surgery or other major medical intervention requiring hospitalisation and/or rehabilitation (e.g., hip replacement).
- Have a history of seizures or epilepsy,
- Require high doses of medication known to lower the threshold for seizures (e.g., amitriptyline \> 100mg/d,
- Have cerebral space occupying lesion,
- Have a history of severe head injury (associated with a suspicion of brain injury, e.g. resulting in unconsciousness for over 24 hrs)
- Have metal located in head (e.g. shrapnel, surgical clips, fragments from welding),
- Have a cochlear implant,
- Have a cardiac pacemaker in situ,
- Have a deep brain or vagal nerve stimulator in situ,
- Are pregnant
Key Trial Info
Start Date :
April 5 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 11 2018
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT03350464
Start Date
April 5 2018
End Date
December 11 2018
Last Update
August 24 2023
Active Locations (1)
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1
The Walton Centre NHS Foundation Trust
Liverpool, Mersey, United Kingdom, L97LJ