Status:
COMPLETED
Enhancing Adaptations to Exercise
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
National Institute on Aging (NIA)
National Center for Research Resources (NCRR)
Conditions:
Inflammation
Eligibility:
All Genders
20-85 years
Phase:
PHASE3
Brief Summary
Researchers are trying to understand how chronic inflammation affects muscle function and responses to exercise.They are also trying to determine if suppressing chronic inflammation using omega-3 fatt...
Detailed Description
Participants will be divided into two groups. Men and women between the ages of 20-35 years and 65-85 years. Participants in the older age group will be randomly assigned to receive groups (n3-PUFA or...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Men and women between the ages of 20-35 years
- Men and women between the ages of 65-85 years
- Exclusion criteria:
- Regular use of omega-3 nutritional supplements
- Diabetes or fasting plasma glucose \> or equal to 126 mg/dL
- Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl)
- Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
- Renal failure (serum creatinine \> 1.5mg/dl)
- Chronic active liver disease (AST\>144 IU/L or ALT\>165 IU/L)
- Oral warfarin group medications or history of blood clotting disorders.
- international normalized ratio (INR) \>2.01.5
- Smoking
- Pregnancy or breastfeeding
- Alcohol consumption greater than 2 glasses/day or other substance abuse
- Untreated or uncontrolled hypothyroidism
- Debilitating chronic disease (at the discretion of the investigators)
- Fish or shellfish allergy
Exclusion
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2021
Estimated Enrollment :
63 Patients enrolled
Trial Details
Trial ID
NCT03350906
Start Date
January 1 2018
End Date
December 31 2021
Last Update
November 14 2023
Active Locations (1)
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1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905