Status:
UNKNOWN
Multicenter Normal Reference Study of Carotid Artery Ultrafast Pulse Wave Velocity (UFPWV)
Lead Sponsor:
Shengjing Hospital
Collaborating Sponsors:
SuperSonic Imagine
Conditions:
Carotid Artery Diseases
Healthy Volunteers
Eligibility:
All Genders
18-79 years
Brief Summary
To establish the range of BS and ES (m/s) of normal carotid artery by using ultrafast pulse wave velocity (UFPWV), and to explore the influencing factors.
Detailed Description
With the gradual aging of Chinese population and continuous development of economy and society, the incidence of cardiovascular disease and the number of patients have increased rapidly. The National ...
Eligibility Criteria
Inclusion
- Han nationality
- Age between 18 and 79 years old
- Normal body mass index (18-25 kg/m2)
- Normal blood pressure (139-90/89-60 mmHg)
- No history of cardiovascular disease or respiratory diseases
- Physical examination reveals no abnormalities in cardiovascular and respiratory systems
- Normal blood glucose, blood lipid and electrocardiogram (ECG)
- Echocardiography shows no structural heart disease and normal cardiac function
- Normal carotid ultrasound
- No history of cardiovascular drug use
Exclusion
- Heart valve regurgitation with clinical significance or moderate symptom and above
- Respiratory system disease: acute or chronic respiratory disease
- Endocrine diseases: thyroid disease, diabetes mellitus, aldosteronism, pheochromocytoma, and adrenal cortex dysfunction.
- Metabolic syndrome
- Anemia
- Pregnant or lactating women
- Abnormal liver function (more than twice the normal upper limit), abnormal renal function (creatinine \> 2 mg/dl), total cholesterol \> 190 mg/dl. If Pro-BNP is detected, Pro-BNP is abnormal or in high limit of normal value.
- Connective tissue disease
- Tumor
- Aortic and peripheral vascular diseases: aortic dilatation, aortic dissection, coarctation of the aorta, polyarteritis, atherosclerosis
- Daily drinking: liquor greater than 50 ml; red wine more than 100 ml; beer more than 300 ml
- Professional sportsman
- The poor quality of ultrasonic images cannot meet parameter measurement and analysis
Key Trial Info
Start Date :
October 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
1200 Patients enrolled
Trial Details
Trial ID
NCT03351127
Start Date
October 1 2017
End Date
December 31 2024
Last Update
May 29 2020
Active Locations (44)
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1
The First Affiliated Hospital of Bengbu Medical College
Bengbu, Anhui, China, 233004
2
Civil Aviation General Hospital
Beijing, Beijing Municipality, China
3
University-Town Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China, 401331
4
Central Hospital of Chongqing Three Gorges
Chongqing, Chongqing Municipality, China, 404000