Status:
COMPLETED
Preemptive Tapentadol on Post-operative Analgesia Following Total Knee Arthroplasty
Lead Sponsor:
All India Institute of Medical Sciences, Bhubaneswar
Conditions:
Analgesia
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The study intends to evaluate the efficacy of Tapentadol against placebo as a preemptive analgesic in the management of post-operative pain in the patiens undergoing total knee arthroplasty. The prim...
Detailed Description
METHODOLOGY * Consent: Participants will be explained the benefit and harm of joining the study and the freedom of withdrawing from the study at any moment they would like to. A full voluntary writte...
Eligibility Criteria
Inclusion
- Patients of either sex undergoing elective tota knee replacement surgery
- Patients are capable to provide an informed consent
- Age 18-65 years
Exclusion
- Patients with Asthma, copd or any other respiratory disease
- Persistent nausea , vomiting at the time of randomization
- Treated with MAO inhibitors, Tricyclic antidepressants, SSRIs and SNRIs
- Patients with ASA grading 3 or more
- Drug abuse history, opioid tolerance or dependence, known history of opiod allergies
- Renal or liver disease
- Major psychiatric disorder
- Pregnancy and lactation
- Emergency surgery
- Bone tumor, epilepsy or patients with migraine
Key Trial Info
Start Date :
November 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 7 2018
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT03351517
Start Date
November 1 2017
End Date
September 7 2018
Last Update
September 10 2018
Active Locations (1)
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1
All India Institute of Medical Sciences
Bhubaneswar, Odisha, India, 751019