Status:
COMPLETED
Impact of New Biomarkers on Maintenance of Sinus Rhythm After Cardioversion or Ablation of Atrial Fibrillation
Lead Sponsor:
Centre Hospitalier Universitaire de Besancon
Conditions:
Atrial Fibrillation
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The Biorhythm study aims to investigate the utility of new biomarkers (e.g. MR proANP, ST2) measured pre-procedure for the prediction of procedural success in patients with atrial fibrillation undergo...
Detailed Description
This is a prospective, observational, multicentre study of patients with paroxystic or persistent atrial fibrillation scheduled to undergo cardioversion or ablation of AF in routine practice. Serum le...
Eligibility Criteria
Inclusion
- Patients with paroxystic or persistent atrial fibrillation for whom a decision to perform ablation is made.
- Patients with persistent atrial fibrillation for whom a decision to perform cardioversion is made.
- Patients with social security coverage, or beneficiary thereof.
- Patients who provide written informed consent.
Exclusion
- Age \<18 years or \>80 years
- Patients with significant valvular heart disease defined as symptomatic aortic valve disease, severe aortic or mitral stenosis or tricuspid or mitral insufficiency grade 3/4 or 4/4
- Patients with pulmonary arterial hypertension \>45 mmHg on echocardiography
- Patients with chronic respiratory disease, chronic obstructive pulmonary disease stage II, III or IV.
- Patients with a left ventricular ejection fraction \<45%
- Patients with recent (\<1 month) acute decompensation of heart failure
- Patients with recent (\<1 month) acute coronary syndrome
- Anemia (hemoglobin \<10 g/dL)
- Pregnant or lactating women
- Patients with anticipated poor compliance, as assessed by the study investigator
- Patients within the exclusion period of another clinical study
- Patients under legal guardianship
Key Trial Info
Start Date :
December 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2020
Estimated Enrollment :
106 Patients enrolled
Trial Details
Trial ID
NCT03351816
Start Date
December 1 2017
End Date
June 1 2020
Last Update
December 23 2020
Active Locations (3)
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1
University Hospital Jean Minjoz
Besançon, France, 25000
2
CHU François Mitterand
Dijon, France
3
CHU Brabois
Vandœuvre-lès-Nancy, France