Status:
COMPLETED
Positron Emission Tomography / Magnetic Resonance Imaging in Aortic Stenosis
Lead Sponsor:
University of Edinburgh
Conditions:
Aortic Stenosis
Transthyretin Amyloidosis
Eligibility:
All Genders
70+ years
Brief Summary
Aortic stenosis is the most common valve disease requiring surgery in the Western world. It is defined by progressive calcification and fibrosis of the valve leaflets and restricted valve opening. Thi...
Eligibility Criteria
Inclusion
- Inclusion Criteria (AS group)
- Severe aortic stenosis
- Referred for aortic valve intervention (surgical AVR / TAVI)
- High clinical suspicion of amyloid (e.g. low-flow low-gradient AS, inappropriate LVH)
- Age \>70 years
- Willing and able to comply with study protocol
- Exclusion Criteria (AS group)
- Inability to give informed consent
- Contraindication to MRI scanning (e.g. permanent pacemaker)
- Significant renal impairment (eGFR \<30 ml/min/1.73 m2)
- Coexistent moderate or severe aortic regurgitation or mitral stenosis
- Acute valvular heart disease (e.g. acute mitral regurgitation or endocarditis)
- Acute pulmonary oedema or cardiogenic shock
- Inclusion Criteria (Healthy volunteers)
- No symptoms suggesting current cardiovascular disease
- Age \>70
- Willing and able to comply with study protocol
- Exclusion Criteria (Healthy volunteers)
- Inability to give informed consent
- Contraindication to MRI scanning (e.g. permanent pacemaker)
- Significant renal impairment (eGFR \<30 ml/min/1.73 m2)
- Known significant valvular heart disease (more than mild regurgitant valve lesion or any stenotic lesion)
Exclusion
Key Trial Info
Start Date :
November 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 23 2018
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT03352089
Start Date
November 1 2017
End Date
August 23 2018
Last Update
June 11 2024
Active Locations (1)
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1
University of Edinburgh / NHS Lothian
Edinburgh, Midlothian, United Kingdom, EH164SB