Status:
COMPLETED
Individualized Incremental Hemodialysis Study
Lead Sponsor:
Alexandria University
Collaborating Sponsors:
Kidney and urology Center
Mansoura University
Conditions:
Hemodialysis Complication
ESRD
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Thrice weekly hemodialysis has been the standard of care all-over the world for end-stage renal disease (ESRD) requiring renal replacement therapy (RRT). Despite being in the era of precision medicine...
Detailed Description
This project aims to study the feasibility, safety and efficacy of individualized incremental (twice weekly, once weekly, once/10days or less frequent) hemodialysis (IIHD) initiation versus convention...
Eligibility Criteria
Inclusion
- Patients with stage 5 chronic kidney disease (CKD) with estimated glomerular filtration rate of less than 10 ml/min/1.73m2 (using CKD-EPI equation for eGFR).
- Residual urine volume at least 0.5 L/day or more.
Exclusion
- Children \< 18 years of age.
- Patients who were previously on other types of RRT, either on peritoneal dialysis, or on kidney transplant.
- Recent (within 3 months) acute kidney injury (AKI).
- Urine output less than 0.5 L/day.
- Active malignancy at time of inclusion.
- Active inflammatory disease with immunosuppressive treatment.
- Decompensated Liver disease, Hepatorenal syndrome.
- Cardiovascular disease defined as: heart failure type IV of the New York Heart Association (NYHA) or Cardiorenal syndrome.
Key Trial Info
Start Date :
June 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2020
Estimated Enrollment :
122 Patients enrolled
Trial Details
Trial ID
NCT03352271
Start Date
June 1 2017
End Date
December 1 2020
Last Update
January 13 2021
Active Locations (2)
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1
Mansoura University
Mansourah, Alexandria Governorate, Egypt, 21529
2
kidney and Urology Center
Alexandria, Egypt