Status:
UNKNOWN
Comparison of Therapeutic Effects Between Intravitreal Injection of Bevacizumab With Intravitreal Injection of Bevacizumab and Targeted Laser Photocoagulation of Non Perfused Areas of Retina in Patients With Acute Retinal Vein Occlusion
Lead Sponsor:
Shahid Beheshti University of Medical Sciences
Conditions:
Retinal Vein Occlusion With Macular Edema
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
PHASE3
Brief Summary
Patients with new onset retinal vein occlusion in less than 3 month whom has visual acuity less than 20/40 and central macular thickness more than 250micrometer and non perfused areas of retina more t...
Eligibility Criteria
Inclusion
- Center-involved macular edema secondary to RVO on clinical exam
- Symptoms less than 3 months
- BCVA= 20/40 or worse
- Mean center point thickness \>250 μm
- Media clarity, pupillary dilation, and subject cooperation sufficient for adequate fundus photographs
- One eye per participant is enrolled in the trial
Exclusion
- Macular edema due to a cause other than CRVO
- An ocular condition such that visual acuity would not improve from resolution of the edema (eg, foveal atrophy)
- Substantial cataract estimated to have reduced visual acuity by \>3 lines
- Prior treatment with intravitreal or peribulbar steroid injection
- History of macular photocoagulation or PRP
- Prior pars plana vitrectomy
- Hx of Intraocular surgery (including cataract extraction)
- uveitis, NVG, exudative AMD, diabetic retinopathy, any malignancy, optic neuropathy, amblyopia
- vitreomacular traction or epiretinal membrane \*uncontrolled glaucoma ( \> 30mmHg with anti-glaucoma medications)
Key Trial Info
Start Date :
November 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2018
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT03353324
Start Date
November 1 2017
End Date
September 1 2018
Last Update
May 31 2018
Active Locations (1)
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1
Ophthalmic Research Center
Tehran, Iran