Status:
COMPLETED
Mechanisms of Mindfulness-Based Cognitive Therapy in the Treatment of Recurrent Major Depressive Disorder
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
University of Oxford
VIA University College
Conditions:
Major Depressive Disorder, Recurrent
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The primary purpose of this study is to investigate neural mechanisms and predictors of treatment outcome in Mindfulness-Based Cognitive Therapy (MBCT) for recurrent Major Depressive Disorder.
Detailed Description
AIM AND HYPOTHESES The primary aim is to investigate treatment mechanisms of MBCT and markers of relapse risk. Controlled design: First, we aim to first investigate the effect of treatment on clini...
Eligibility Criteria
Inclusion
- Age above 18 years
- Meeting DSM-IV criteria for a history of recurrent Major Depressive Disorder (MDD) with or without a current episode of depression
- Recurrent MDD evaluated a being the primary disorder.
- Danish literacy
Exclusion
- A history of schizophrenia, schizoaffective disorder, bipolar disorder, current severe substance abuse, organic mental disorder, current/past psychosis, pervasive developmental delay, persistent antisocial behaviour, persistent self-injury requiring clinical management/therapy
- Formal concurrent psychotherapy
- Previous Mindfulness-Based Cognitive Therapy/Mindfulness-Based Stress Reduction
- Anti-psychotic medication and benzodiazepines
- Standard exclusion criteria for undergoing magnetic resonance imaging (MRI) procedures for research purposes, i.e., claustrophobia, pregnancy, cardiac pacemaker, prosthetic heart valve, neurostimulator, implanted pumps, cochlear implants, non-MR-compatible implants or devices.
Key Trial Info
Start Date :
February 15 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2019
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT03353493
Start Date
February 15 2017
End Date
June 1 2019
Last Update
June 5 2019
Active Locations (1)
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1
Aarhus University
Aarhus, Denmark, 8000