Status:
UNKNOWN
Use of Sodium Bicarbonate in Patients Treated With Topiramate
Lead Sponsor:
McMaster Children's Hospital
Conditions:
Epilepsy
Metabolic Acidosis
Eligibility:
All Genders
2-18 years
Phase:
NA
Brief Summary
Effect of oral sodium bicarbonate therapy on renal tubular acidosis in epilepsy patients taking topiramate.
Detailed Description
Children on topiramate are at a risk of renal tubular acidosis and subsequent development of renal stones. Sodium bicarbonate has been shown to reduce renal tubular acidosis in other populations. To d...
Eligibility Criteria
Inclusion
- Patients with epilepsy receiving oral topiramate for a minimum of 3 months
Exclusion
- pre-existing renal impairments (ie nephropathy, primary nephritis)
- receiving other medications or diet therapies that may influence renal function or urine acidity/ citrate concentration
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2018
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03354507
Start Date
January 1 2018
End Date
December 1 2018
Last Update
November 28 2017
Active Locations (1)
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1
McMaster Children's Hospital
Hamilton, Ontario, Canada, L8N 3Z5