Status:
COMPLETED
The Role of the Circadian System in Neurological Sleep-wake Disorders
Lead Sponsor:
Esther Werth
Conditions:
Narcolepsy 1
Idiopathic Hypersomnia
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
The aim of this study is to investigate the role of the circadian system in patients with neurologic sleep-wake disorders. Therefore, overnight sleep will be distributed over 30 hours into repetitive ...
Eligibility Criteria
Inclusion
- Male and Female participants 18 years to 35 years of age
- Written informed consent by the participant after information about the research project
- Healthy controls: 7-8 hours of sleep per night
- Healthy controls: sleep satiation before start of the study
- Narcolepsy type 1: diagnosis of narcolepsy with cataplexy, drug free during study, proven excessive daytime sleepiness with increased REM (MSLT), clear-cut cataplexy present, undetectable or low cerebrospinal fluid hypocretin levels (if data is available)
- Idiopathic hypersomnia: diagnosis of idiopathic hypersomnia, drug free during study, proven excessive daytime sleepiness without increased REM (MSLT), increased sleep need (\>10h/day) on work-free days shown by 2-week actigraphy
Exclusion
- signs of neurological, psychiatric, or other sleep-wake disorders
- signs of sleep deprivation
- shift work and time zone change of more than one hour within one month prior the study start
- extreme morning and evening types
- underweight
- obstructive gastro-intestinal disease or history of gastrointestinal surgery
- an implanted medical device or a scheduled MRI scan during the experimental period
Key Trial Info
Start Date :
November 28 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2020
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT03356938
Start Date
November 28 2017
End Date
May 31 2020
Last Update
February 21 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Hospital Zurich
Zurich, Switzerland, 8091