Status:
UNKNOWN
The Maximum Tolerated Dose of Mesenchymal Stem Cells From Umbilical Cord
Lead Sponsor:
Peking University People's Hospital
Conditions:
Knee Osteoarthritis
Umbilical Cord Bleeding
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The aim of this study was to evaluate the maximum tolerated dose of Mesenchymal Stem Cells (MSCs) from umbilical cord in the treatment of human knee OA
Detailed Description
This is a single-centre, quadruple blined, randomized controlled trail with a total of 9 knee osteoarthrits patients as participants, who will be randomly assigned into high dose group, moderate dose ...
Eligibility Criteria
Inclusion
- ① K / L score of 2-3; ② chronic knee pain; ③ no local or systemic infection; ④ without obvious contraindication of the joint puncture from hematology and biochemical tests; ⑤ informed consent. -
Exclusion
- ① older than 75 years old or less than 18 years old, or without full capacity for civil conduct; ② HIV, hepatitis virus or syphilis virus infection or their serology is positive; ③ BMI index is greater than 30; ④ congenital or acquired knee deformity; ⑤ pregnant or lactating women; ⑥ tumor patients; ⑦ immunodeficiency patients; ⑧ intra-articular drug injection history within 3 months; ⑨ participating in other clinical trials; ⑩ other patients who researchers believe are not eligible for inclusion such as suffering from other concomitant diseases.-
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2021
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT03357770
Start Date
January 1 2018
End Date
June 1 2021
Last Update
November 30 2017
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