Status:
RECRUITING
Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)
Lead Sponsor:
Fondation Ophtalmologique Adolphe de Rothschild
Conditions:
Conjunctival Diseases
Dry Eye Syndromes
Eligibility:
All Genders
18+ years
Brief Summary
Modifications of cell surface markers (including EMMPRIN) were observed in conjunctival epithelial cells during dry eye syndrome ; this study aims to describe the modifications of the repartition of t...
Eligibility Criteria
Inclusion
- Patients:
- Inclusion criteria
- 18 years and over
- Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level, marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes
- Patients without eye treatment or patients undergoing long-term stable eye treatment for whom a new treatment is being introduced
- Exclusion criteria - Known pregnancy or breastfeeding
- Control subjects:
- Inclusion criteria
- \- 18 years and over
- Exclusion criteria
- Wearer of contact lenses
- Topical ocular treatment
- Known pregnancy or breastfeeding
Exclusion
Key Trial Info
Start Date :
December 14 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2027
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03358979
Start Date
December 14 2017
End Date
March 1 2027
Last Update
December 8 2025
Active Locations (1)
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1
Fondation Ophtalmologique A de Rothschild
Paris, France, 75019