Status:
UNKNOWN
Correlation of Eicosanoid and Proresolving Lipid Mediator Temporal Profiles and Resolution of Pain After Thoracic Surgery
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Pain, Postoperative
Eligibility:
All Genders
18-85 years
Brief Summary
The aim of the current pilot study is to investigate whether perioperative dysregulated systemic lipid mediator pathways (more specifically increased pro-inflammatory and decreased anti-inflammatory p...
Detailed Description
This is a prospective, observational pilot study that will assess whether 1) a peri-operative dysregulated metabolo-lipidomics or SPM profile is associated with slower resolution of pain after surgery...
Eligibility Criteria
Inclusion
- Age 18-85
- Patients scheduled to undergo thoracic surgery at Brigham and Women's Hospital
Exclusion
- Pre-existing chronic pain or opioid use
- Current treatment with corticosteroids
- Evidence of active infection
- Chronic liver disease, end-stage renal disease (CKD-5), or chronic inflammatory disorders
- Recent major surgery or illness within 30 days
- Use of immunosuppressive medication
- History of organ transplantation.
Key Trial Info
Start Date :
December 11 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2019
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03360175
Start Date
December 11 2017
End Date
December 1 2019
Last Update
December 4 2017
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