Status:
UNKNOWN
Timing of Surgery in Nonmetastatic Osteosarcoma of the Pelvis and Sacrum
Lead Sponsor:
Peking University People's Hospital
Conditions:
Osteosarcoma of Pelvis
Eligibility:
All Genders
10-40 years
Phase:
NA
Brief Summary
To study the effect of the timing of surgery on outcome of patients with nonmetastatic osteosarcoma of pelvis and sacrum.
Detailed Description
Successful therapeutic interventions to prevent disease progression in patients with nonmetastatic osteosarcoma of pelvis and sacrum have included surgery with adjuvant chemotherapy. Pre-surgical chem...
Eligibility Criteria
Inclusion
- Age \>10 years and \<40 years;
- High-grade nonmetastatic osteosarcoma in pelvis or sacrum;
- Diagnosis confirmed histologically and reviewed centrally;
- No evidence of metastatic disease with computed tomography scan of the chest and radionuclide bone scan, or Positron Emission Tomography (PET/CT) within 2 weeks of entry;
- No prior therapy;
- Eastern Cooperative Oncology Group performance status 0-1;
- Life expectancy \>3 months;
- Adequate renal, hepatic, and hemopoietic function;
Exclusion
- Previously treated by chemotherapy or unplanned surgery in other hospital;
- Have had other kinds of malignant tumors at the same time;
- Uncontrolled complications, such as diabetes mellitus and so on;
- Intravascular tumor thrombus on enhanced CT or magnetic resonance (MR);
- Unresectable disease evaluated by surgeons.
Key Trial Info
Start Date :
August 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03360760
Start Date
August 1 2018
End Date
February 1 2025
Last Update
August 28 2018
Active Locations (1)
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1
Peking University People's Hospital
Beijing, Beijing Municipality, China, 100034